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Case Report
Follicular dendritic cell sarcoma of the tonsil: A case report of uncommon tumor displaying diagnostic features and review of the literature
1 Department of Pathology, American University of the Caribbean, Pembroke Pines, Florida, USA
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Morgan Sly
American University of the Caribbean, 1 University Drive at Jordan Road, Cupecoy, St. Maarten, Pembroke Pines, Florida,
USA
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Article ID: 100063Z06MS2019
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Sly M, Wichelt E, Spears J, Clark K, Aziz M. Follicular dendritic cell sarcoma of the tonsil: A case report of uncommon tumor displaying diagnostic features and review of the literature. Case Rep Int 2019;8:100063Z06MS2019.ABSTRACT
Introduction: Follicular dendritic cells are non-hematopoietic cells that are found in germinal centers and function in the differentiation and development of activated B cells. Follicular dendritic cell sarcoma is a rare neoplasm, typically, located in lymph nodes throughout the body. Follicular dendritic cell sarcomas can also be found in extranodal sites. Follicular dendritic cell sarcomas located in extranodal sites are underdiagnosed due to the rarity and lack of consideration in differential diagnoses. Additionally, up to one-third of extranodal cases are misdiagnosed.
Case Report: We are presenting a case of follicular dendritic cell sarcoma located in the tonsil of a 73-year-old male. Examination revealed a tonsillar mass suspicious for squamous cell carcinoma, malignant melanoma, or anaplastic lymphoma. Biopsy of the tonsil was performed and the patient was diagnosed with a low-grade malignant tumor exhibiting morphologic and immunohistochemical features indicative of dendritic/reticulum cell origin.
Conclusion: The reporting of this case aims to increase knowledge and awareness regarding the morphologic and immunohistochemical features of rare and often misdiagnosed extranodal follicular dendritic cell sarcomas. Heightened awareness of this tumor will lead to inclusion as a differential diagnosis of the initial evaluation of biopsy with this tumor features and avoid misdiagnosis.
Keywords: Dendritic, Extranodal, Follicular, Sarcoma, Tonsil
SUPPORTING INFORMATION
Author Contributions
Morgan Sly - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Emily Wichelt - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jamie Spears - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Kiley Clark - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mohamed Aziz - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Source of SupportNone
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Morgan Sly et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
